A Mendelian analysis of the relationships between immune cells and breast cancer.

ABSTRACT:

Background

Emerging evidence showed immune cells were associated with the development of breast cancer. Nonetheless, the causal link between them remains uncertain. Consequently, the objective of this study was to investigate the causal connection between immune traits and the likelihood of developing breast cancer.

Methods

A two-sample Mendelian randomization (MR) analysis was conducted to establish the causal relationship between immune cells and breast cancer in this study. Utilizing publicly accessible genetic data, we investigated causal connections between 731 immune cells and the occurrence of breast cancer. The primary approach for exploring this relationship was the application of the inverse-variance-weighted (IVW) method. Furthermore, sensitivity analyses, encompa

SUBMITTER: Wang X 

PROVIDER: S-EPMC10847340 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature