Dataset Information

Out-of-Hospital cardiac arrest & SmartphonE RespOndErS trial (HEROES Trial): Methodology and study protocol of a pre-post-design trial of the effect of implementing a smartphone alerting system on survival in out-of-hospital cardiac arrest.

ABSTRACT:

Background

Since 2021, international guidelines for cardiopulmonary resuscitation recommend the implementation of so-called "life-saving systems". These systems include smartphone alerting systems (SAS), which enable dispatch centres to alert first responders via smartphone applications, who are in proximity of a suspected out-of-hospital cardiac arrest (OHCA). However, the effect of SAS on survival remains unknown.

Aim

The aim is to assess the rate of survival to hospital discharge in adult patients with OHCA not witnessed by emergency medical services (EMS): before and after SAS implementation.

Design

Multicentre, prospective, observational, intention-to-treat, pre-post design clinical trial.

Population

Adults (aged ≥ 18 years), OHCA not witnessed by EMS, no traumatic cause for cardiac arrest, cardiopulmonary resuscitation initiated or continued by EMS.

Setting

Dispatch-centre-based.

Outcomes

Primary: survival to hospital discharge. Secondary: time to first compression, rate of basic life support measures before EMS arrival, rate of patients with shockable rhythm at EMS arrival, Cerebral Performance Category at hospital discharge, and duration of hospital stay.

Sample size

Assuming an absolute difference in survival rates to hospital discharge of 4% in the two groups (11% before implementation of the SAS versus 15% after) and 80% power, and a type 1 error rate of 0.05, the required sample size is N = 1,109 patients per group (at least N = 2,218 evaluated patients in total).

Conclusions

The HEROES trial will investigate the effects of a SAS on the survival rate after OHCA.

Trial registration

German Clinical Trials Register (DRKS, ID: DRKS00032920).

SUBMITTER: Muller MP

PROVIDER: S-EPMC10847368 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature

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Publications

Out-of-<b>H</b>ospital cardiac arrest & Smartphon<b>E R</b>esp<b>O</b>nd<b>E</b>r<b>S</b> trial (<b>HEROES</b> Trial): Methodology and study protocol of a pre-post-design trial of the effect of implementing a smartphone alerting system on survival in out-of-hospital cardiac arrest.

Müller Michael P MP Ganter Julian J Busch Hans-Jörg HJ Trummer Georg G Sahlmann Jörg J Brettner Florian F Reden Maria M Elschenbroich Daniel D Preusch Michael M Rusnak Jonas J Katzenschlager Stephan S Nauheimer Dirk D Wunderlich Robert R Pooth Jan-Steffen JS

Resuscitation plus 20240201

<h4>Background</h4>Since 2021, international guidelines for cardiopulmonary resuscitation recommend the implementation of so-called "life-saving systems". These systems include smartphone alerting systems (SAS), which enable dispatch centres to alert first responders via smartphone applications, who are in proximity of a suspected out-of-hospital cardiac arrest (OHCA). However, the effect of SAS on survival remains unknown.<h4>Aim</h4>The aim is to assess the rate of survival to hospital dischar ...[more]

PMID: 38328746

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