Senolytics: from pharmacological inhibitors to immunotherapies, a promising future for patients' treatment.

ABSTRACT: The involvement of cellular senescence in the initiation and propagation of diseases is clearly characterized, making the elimination of senescent cells essential to treat age-related diseases. The development of senolytic drugs demonstrated that targeting these cells limits the deterioration of patients' condition, by inducing apoptosis. Nevertheless, the first generations of senolytics which has been developed displayed their activities through specific mechanisms and demonstrated several limitations during clinical development. However, the rational to eliminate senescent cells remains evident, with the necessity to develop specific therapies in a context of diseases and tissues. The evolutions in the field of drug discovery open the way to a new generation of senolytic therapies, such

SUBMITTER: Lelarge V 

PROVIDER: S-EPMC10847408 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature