Dependence of human cell survival and proliferation on the CASP3 prodomain.

ABSTRACT: Mechanisms that regulate cell survival and proliferation are important for both the development and homeostasis of normal tissue, and as well as for the emergence and expansion of malignant cell populations. Caspase-3 (CASP3) has long been recognized for its proteolytic role in orchestrating cell death-initiated pathways and related processes; however, whether CASP3 has other functions in mammalian cells that do not depend on its known catalytic activity have remained unknown. To investigate this possibility, we examined the biological and molecular consequences of reducing CASP3 levels in normal and transformed human cells using lentiviral-mediated short hairpin-based knockdown experiments in combination with approaches designed to test the potential rescue capability of different compone

SUBMITTER: Eskandari E 

PROVIDER: S-EPMC10847432 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature