Development of novel polymer haemoglobin based particles as an antioxidant, antibacterial and an oxygen carrier agents.

ABSTRACT: This innovative work aims to develop highly biocompatible and degradable nanoparticles by encapsulating haemoglobin (Hb) within poly-ε-caprolactone for novel biomedical applications. We used a modified double emulsion solvent evaporation method to fabricate the particles. A Scanning electron microscope (SEM) characterized them for surface morphology. Fourier Transform Infrared Spectroscopy (FTIR) and Ultraviolet-visible spectroscopies (UV-visible) elucidated preserved chemical and biological structure of encapsulated haemoglobin. The airproof equilibrium apparatus obtained the oxygen-carrying capacity and P₅₀ values. The DPPH assay assessed free radical scavenging potential. The antibacterial properties were observed using four different bacterial strains by disk diffusion metho

SUBMITTER: Majid MA 

PROVIDER: S-EPMC10847508 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature