Unilateral hippocampal sparing during whole brain radiotherapy for multiple brain metastases: narrative and critical review.

ABSTRACT:

Background

The landscape of brain metastases radiotherapy is evolving, with a shift away from whole-brain radiotherapy (WBRT) toward targeted stereotactic approaches aimed at preserving neurocognitive functions and maintaining overall quality of life. For patients with multiple metastases, especially in cases where targeted radiotherapy is no longer feasible due to widespread dissemination, the concept of hippocampal sparing radiotherapy (HA_WBRT) gains prominence.

Methods

In this narrative review we explore the role of the hippocampi in memory formation and the implications of their postradiotherapy lateral damage. We also consider the potential advantages of selectively sparing one hippocampus during whole-brain radiotherapy (WBRT). Additionally, by systematic evaluation o

SUBMITTER: Pospisil P 

PROVIDER: S-EPMC10847587 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature