Prediagnostic plasma metabolite concentrations and liver cancer risk: a population-based study of Chinese men.

ABSTRACT:

Background

Previous metabolic profiling of liver cancer has mostly used untargeted metabolomic approaches and was unable to quantitate the absolute concentrations of metabolites. In this study, we examined the association between the concentrations of 186 targeted metabolites and liver cancer risk using prediagnostic plasma samples collected up to 14 years prior to the clinical diagnosis of liver cancer.

Methods

We conducted a nested case-control study (n = 322 liver cancer cases, n = 322 matched controls) within the Shanghai Men's Health Study. Conditional logistic regression models adjusted for demographics, lifestyle factors, dietary habits, and related medical histories were used to estimate the odds ratios. Restricted cubic spline functions were used to characterise the

SUBMITTER: Li ZY 

PROVIDER: S-EPMC10847612 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature