Definitive hematopoiesis is dispensable to sustain erythrocytes and macrophages during zebrafish ontogeny.

ABSTRACT: In all organisms studied, from flies to humans, blood cells emerge in several sequential waves and from distinct hematopoietic origins. However, the relative contribution of these ontogenetically distinct hematopoietic waves to embryonic blood lineages and to tissue regeneration during development is yet elusive. Here, using a lineage-specific "switch and trace" strategy in the zebrafish embryo, we report that the definitive hematopoietic progeny barely contributes to erythrocytes and macrophages during early development. Lineage tracing further shows that ontogenetically distinct macrophages exhibit differential recruitment to the site of injury based on the developmental stage of the organism. We further demonstrate that primitive macrophages can solely maintain tissue regeneration durin

SUBMITTER: Elsaid R 

PROVIDER: S-EPMC10847700 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature