The SWI/SNF nucleosome remodeler constrains enhancer activity during Drosophila wing development.

ABSTRACT: Chromatin remodeling is central to the dynamic changes in gene expression that drive cell fate determination. During development, the sets of enhancers that are accessible for use change globally as cells transition between stages. While transcription factors and nucleosome remodelers are known to work together to control enhancer accessibility, it is unclear how the short stretches of DNA that they individually unmask yield the kilobase-sized accessible regions characteristic of active enhancers. Here, we performed a genetic screen to investigate the role of nucleosome remodelers in control of dynamic enhancer activity. We find that the Drosophila Switch/Sucrose Non-Fermenting complex, BAP, is required for repression of a temporally dynamic enhancer, brdisc. Contrary to expectations, we f

SUBMITTER: Niederhuber MJ 

PROVIDER: S-EPMC10847718 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature