Introduction of <i>Aedes aegypti</i> mosquitoes carrying <i>w</i>AlbB <i>Wolbachia</i> sharply decreases dengue incidence in disease hotspots.

ABSTRACT: Partial replacement of resident Aedes aegypti mosquitoes with introduced mosquitoes carrying certain strains of inherited Wolbachia symbionts can result in transmission blocking of dengue and other viruses of public health importance. Wolbachia strain wAlbB is an effective transmission blocker and stable at high temperatures, making it particularly suitable for hot tropical climates. Following trial field releases in Malaysia, releases using wAlbB Ae. aegypti have become operationalized by the Malaysian health authorities. We report here on an average reduction in dengue fever of 62.4% (confidence intervals 50-71%) in 20 releases sites when compared to 76 control sites in high-rise residential areas. Importantly the level of dengue reduction increa

SUBMITTER: Hoffmann AA 

PROVIDER: S-EPMC10847733 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature