Development of sensorimotor-visual connectome gradient at birth predicts neurocognitive outcomes at 2 years of age.

ABSTRACT: Functional connectome gradients represent fundamental organizing principles of the brain. Here, we report the development of the connectome gradients in preterm and term babies aged 31-42 postmenstrual weeks using task-free functional MRI and its association with postnatal cognitive growth. We show that the principal sensorimotor-to-visual gradient is present during the late preterm period and continuously evolves toward a term-like pattern. The global measurements of this gradient, characterized by explanation ratio, gradient range, and gradient variation, increased with age (p < 0.05, corrected). Focal gradient development mainly occurs in the sensorimotor, lateral, and medial parietal regions, and visual regions (p < 0.05, corrected). The connectome gradient at birth predicts cognitive

SUBMITTER: Xia Y 

PROVIDER: S-EPMC10847735 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature