Expanding donor options: haploidentical transplant recipients are also highly likely to have a 7/8-matched unrelated donor.

ABSTRACT:

Abstract

The use of haploidentical related donor (HRD) hematopoietic cell transplants (HCTs) in the United States grew by more than fourfold in the last decade, driven mainly by use of posttransplant cyclophosphamide (PTCy)-based graft-versus-host-disease prophylaxis. However, not all patients have a suitable HRD available. In this study, we explored the existence of unrelated donors (URDs) on the National Marrow Donor Program (NMDP) registry at the 8/8- or 7/8-match level for patients receiving HRD HCT in the United States and reporting to the Center for International Blood and Marrow Transplant Research between 2013 and 2020. The data consist of 9696 HRD HCT recipients. The NMDP search prognosis score and a search simulation were used to estimate counts of URD matches on the regi

SUBMITTER: Fingerson S 

PROVIDER: S-EPMC10847856 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature