Living in trinity of extremes: Genomic and proteomic signatures of halophilic, thermophilic, and pH adaptation.

ABSTRACT: Since nucleic acids and proteins of unicellular prokaryotes are directly exposed to extreme environmental conditions, it is possible to explore the genomic-proteomic compositional determinants of molecular mechanisms of adaptation developed by them in response to harsh environmental conditions. Using a wealth of currently available complete genomes/proteomes we were able to explore signatures of adaptation to three environmental factors, pH, salinity, and temperature, observing major trends in compositions of their nucleic acids and proteins. We derived predictors of thermostability, halophilic, and pH adaptations and complemented them by the principal components analysis. We observed a clear difference between thermophilic and salinity/pH adaptations, whereas latter invoke seemingly overl

SUBMITTER: Amangeldina A 

PROVIDER: S-EPMC10847869 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature