Pregnancy outcomes and iron status in β-thalassemia major and intermedia: a systematic review and meta-analysis.

ABSTRACT:

Abstract

Advancements in orally bioavailable iron chelators and MRI methods have improved life expectancy and reproductive potential in thalassemia major (TM) and thalassemia intermedia (TI). Pregnancy is associated with adverse maternal and neonatal outcomes, frequency of which has not been well delineated. This systematic review aims to provide risk estimates of maternal and fetal outcomes in TM and TI and explore pregnancy's impact on iron homeostasis. Fifteen studies (429 participants, 684 pregnancies) were included. Meta-analysis revealed a higher thrombosis risk in TI (3.7%) compared to TM (0.92%), unchanged from prepregnancy. Heart failure risks in the earlier years appeared similar (TM 1.6% vs TI 1.1%), and maternal mortality in TM was 3.7%, but with current management, the

SUBMITTER: Vlachodimitropoulou E 

PROVIDER: S-EPMC10847873 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature