White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions.

ABSTRACT:

Introduction

Compared to research on adults with depression, relatively little work has examined white matter microstructure differences in depression arising earlier in life. Here we tested hypotheses about disruptions to white matter structure in adolescents with current and past depression, with an a priori focus on the cingulum bundles, uncinate fasciculi, corpus collosum, and superior longitudinal fasciculus.

Methods

One hundred thirty-one children from the Preschool Depression Study were assessed using a Human Connectome Project style diffusion imaging sequence which was processed with HCP pipelines and TRACULA to generate estimates of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD).

Results

We found that red

SUBMITTER: Barch DM 

PROVIDER: S-EPMC10848013 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature