Association of variability in body size with neuroimaging metrics of brain health: a population-based cohort study.

ABSTRACT:

Background

The relationship between the fluctuation in body size and brain health is poorly understood. This study aimed to examine the associations of long-term variability in body mass index (BMI) and waist-to-hip ratio (WHR) with neuroimaging metrics that approximate brain health.

Methods

This cohort study recruited 1114 participants aged 25-83 years from a multicenter, community-based cohort study in China. We modeled the BMI and WHR trajectories of participants during 2006-2018 and assessed the BMI and WHR variability (direction and speed of change) by calculating the slope. Generalized linear models were applied to investigate the associations of BMI and WHR variability with MRI markers of brain tissue volume, white matter microstructural integrity, white matter hyperi

SUBMITTER: Sun J 

PROVIDER: S-EPMC10848022 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature