The value of FDG combined with PiB PET in the diagnosis of patients with cognitive impairment in a memory clinic.

ABSTRACT:

Aims

To analyze the value of ¹⁸ F-fluorodeoxyglucose (FDG) positron emission tomography (PET) combined with amyloid PET in cognitive impairment diagnosis.

Methods

A total of 187 patients with dementia or mild cognitive impairment (MCI) who underwent ¹¹ C-Pittsburgh compound B (PiB) and FDG PET scans in a memory clinic were included in the final analysis.

Results

Amyloid-positive and amyloid-negative dementia patient groups showed a significant difference in the proportion of individuals presenting temporoparietal cortex (p < 0.001) and posterior cingulate/precuneus cortex (p < 0.001) hypometabolism. The sensitivity and specificity of this hypometabolic pattern for identifying amyloid pathology were 72.61% and 77.97%, respectively, in patients cli

SUBMITTER: Liu F 

PROVIDER: S-EPMC10848040 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature