CIA-II is associated with lower-grade glioma survival and cell proliferation.

ABSTRACT:

Background

The role of CIA-II has been clarified in several types of tumors; however, whether dysregulated CIA-II expression is also involved in the pathophysiology of lower-grade glioma (LGG) remains undisclosed.

Methods

A comprehensive pan-cancer analysis of the expression patterns and prognostic significance of CIA-II in miscellaneous tumors was undertaken. Subsequently, a detailed bioinformatics analysis was executed to identify putative correlations between CIA-II expression and clinical features, prognosis, biological functions, immunological characteristics, genomic alterations, and chemotherapeutics in LGG. In vitro studies were implemented to examine the potential roles of CIA-II in LGG.

Results

CIA-II expression was found to be abnormally elevated in a varie

SUBMITTER: Xiao F 

PROVIDER: S-EPMC10848044 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature