Human umbilical cord derived mesenchymal stem cells overexpressing HO-1 attenuate neural injury and enhance functional recovery by inhibiting inflammation in stroke mice.

ABSTRACT:

Aims

The current evidence demonstrates that mesenchymal stem cells (MSCs) hold therapeutic potential for ischemic stroke. However, it remains unclear how changes in the secretion of MSC cytokines following the overexpression of heme oxygenase-1 (HO-1) impact excessive inflammatory activation in a mouse ischemic stroke model. This study investigated this aspect and provided further insights.

Methods

The middle cerebral artery occlusion (MCAO) mouse model was established, and subsequent injections of MSC, MSC^HO-1 , or PBS solutions of equal volume were administered via the mice's tail vein. Histopathological analysis was conducted on Days 3 and 28 post-MCAO to observe morphological changes in brain slices. mRNA expression levels of various factors, including IL-1β,

SUBMITTER: Yang Y 

PROVIDER: S-EPMC10848045 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature