Sub-dose anesthetics combined with chloride regulators protect the brain against chronic ischemia-hypoxia injury.

ABSTRACT:

Background

Cerebral ischemia-hypoxia leads to excitotoxicity-mediated neuronal damage and cognitive dysfunction, especially in the elderly. Excessive intracellular [Cl^- ]_i accumulation weakens γ-aminobutyric acid (GABA) compensatory effects. Sub-anesthetic dose of propofol protected the brain against ischemia-hypoxia, which was abolished by blocking Cl^- efflux transporter K⁺ /Cl^- cotransporter 2 (KCC2). We aimed to determine whether low-dose anesthetic combined with [Cl^- ]_i regulators could restore the compensatory GABAergic system and improve cognitive function.

Methods

Chronic cerebral hypoxia (CCH) model was established by bilateral carotid artery ligation in aged rats. Sub-dose of anesthetics (p

SUBMITTER: Yang C 

PROVIDER: S-EPMC10848060 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature