Inflammation affects dynamic functional network connectivity pattern changes via plasma NFL in cognitive impairment patients.

ABSTRACT:

Background

Plasma neurofilament light chain (NFL) is a biomarker of inflammation and neurodegenerative diseases such as Alzheimer's disease (AD). However, the underlying neural mechanisms by which NFL affects cognitive function remain unclear. In this study, we investigated the effects of inflammation on cognitive integrity in patients with cognitive impairment through the functional interaction of plasma NFL with large-scale brain networks.

Methods

This study included 29 cognitively normal, 55 LowNFL patients, and 55 HighNFL patients. Group independent component analysis (ICA) was applied to the resting-state fMRI data, and 40 independent components (IC) were extracted for the whole brain. Next, the dynamic functional network connectivity (dFNC) of each subject was estimate

SUBMITTER: Yao W 

PROVIDER: S-EPMC10848064 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature