PGAM5 knockout causes depressive-like behaviors in mice via ATP deficiency in the prefrontal cortex.

ABSTRACT:

Introduction

Major depressive disorder (MDD) affects about 17% population in the world. Although abnormal energy metabolism plays an important role in the pathophysiology of MDD, however, how deficiency of adenosine triphosphate (ATP) products affects emotional circuit and what regulates ATP synthesis are still need to be elaborated.

Aims

Our study aimed to investigate how deficiency of PGAM5-mediated depressive behavior.

Results

We firstly discovered that PGAM5 knockout (PGAM5^-/- ) mice generated depressive-like behaviors. The phenotype was reinforced by the observation that chronic unexpected mild stress (CUMS)-induced depressive mice exhibited lowered expression of PGAM5 in prefrontal cortex (PFC), hippocampus (HIP), and striatum. Next, we found, with th

SUBMITTER: Cui W 

PROVIDER: S-EPMC10848067 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature