The G protein-coupled estrogen receptor of the trigeminal ganglion regulates acute and chronic itch in mice.

ABSTRACT:

Aims

Itch is an unpleasant sensation that severely impacts the patient's quality of life. Recent studies revealed that the G protein-coupled estrogen receptor (GPER) may play a crucial role in the regulation of pain and itch perception. However, the contribution of the GPER in primary sensory neurons to the regulation of itch perception remains elusive. This study aimed to investigate whether and how the GPER participates in the regulation of itch perception in the trigeminal ganglion (TG).

Methods and results

Immunofluorescence staining results showed that GPER-positive (GPER⁺ ) neurons of the TG were activated in both acute and chronic itch. Behavioral data indicated that the chemogenetic activation of GPER⁺ neurons of the TG of Gper-Cre mice abrogate

SUBMITTER: Li J 

PROVIDER: S-EPMC10848076 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature