Iron overload suppresses hippocampal neurogenesis in adult mice: Implication for iron dysregulation-linked neurological diseases.

ABSTRACT:

Aims

Adult hippocampal neurogenesis is an important player in brain homeostasis and its impairment participates in neurological diseases. Iron overload has emerged as an irreversible factor of brain aging, and is also closely related to degenerative disorders, including cognitive dysfunction. However, whether brain iron overload alters hippocampal neurogenesis has not been reported. We investigated the effect of elevated iron content on adult hippocampal neurogenesis and explored the underlying mechanism.

Methods

Mouse models with hippocampal iron overload were generated. Neurogenesis in hippocampus and expression levels of related molecules were assessed.

Results

Iron accumulation in hippocampus remarkably impaired the differentiation of neural stem cells, resulting

SUBMITTER: Li J 

PROVIDER: S-EPMC10848078 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature