Alzheimer's disease diagnostic accuracy by fluid and neuroimaging ATN framework.

ABSTRACT:

Objectives

The ATN's different modalities (fluids and neuroimaging) for each of the Aβ (A), tau (T), and neurodegeneration (N) elements are used for the biological diagnosis of Alzheimer's disease (AD). We aim to identify which ATN category achieves the highest potential for diagnosis and predictive accuracy of longitudinal cognitive decline.

Methods

Based on the availability of plasma ATN biomarkers (plasma-derived Aβ_42/40 , p-tau181, NFL, respectively), CSF ATN biomarkers (CSF-derived Aβ₄₂ /Aβ₄₀ , p-tau181, NFL), and neuroimaging ATN biomarkers (18F-florbetapir (FBP) amyloid-PET, 18F-flortaucipir (FTP) tau-PET, and fluorodeoxyglucose (FDG)-PET), a total of 2340 participants were selected from ADNI.

Results

Our data analysis indicates

SUBMITTER: Xiong X 

PROVIDER: S-EPMC10848089 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature