Performance and Sensitivity of [^99mTc]Tc-sestamibi Compared with Positron Emission Tomography Radiotracers to Measure P-glycoprotein Function in the Kidneys and Liver.

ABSTRACT: P-glycoprotein (P-gp, encoded in humans by the ABCB1 gene and in rodents by the Abcb1a/b genes) is a membrane transporter that can restrict the intestinal absorption and tissue distribution of many drugs and may also contribute to renal and hepatobiliary drug excretion. The aim of this study was to compare the performance and sensitivity of currently available radiolabeled P-gp substrates for positron emission tomography (PET) with the single-photon emission computed tomography (SPECT) radiotracer [^99mTc]Tc-sestamibi for measuring the P-gp function in the kidneys and liver. Wild-type, heterozygous (Abcb1a/b^(+/-)), and homozygous (Abcb1a/b^(-/-)) Abcb1a/b knockout mice

SUBMITTER: Hernandez-Lozano I 

PROVIDER: S-EPMC10848257 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature