Effect of Antigen Valency on Autoreactive B-Cell Targeting.

ABSTRACT: Many autoimmune diseases are characterized by B cells that mistakenly recognize autoantigens and produce antibodies toward self-proteins. Current therapies aim to suppress the immune system, which is associated with adverse effects. An attractive and more specific approach is to target the autoreactive B cells selectively through their unique B-cell receptor (BCR) using an autoantigen coupled to an effector molecule able to modulate the B-cell activity. The cellular response upon antigen binding, such as receptor internalization, impacts the choice of effector molecule. In this study, we systematically investigated how a panel of well-defined mono-, di-, tetra-, and octavalent peptide antigens affects the binding, activation, and internalization of the BCR. To test our constructs, we used

SUBMITTER: van Weijsten MJ 

PROVIDER: S-EPMC10848265 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature