Ontology highlight
ABSTRACT:
SUBMITTER: van Weijsten MJ
PROVIDER: S-EPMC10848265 | biostudies-literature | 2024 Feb
REPOSITORIES: biostudies-literature
van Weijsten M J MJ Venrooij K R KR Lelieveldt L P W M LPWM Kissel T T van Buijtenen E E van Dalen F J FJ Verdoes M M Toes R E M REM Bonger K M KM
Molecular pharmaceutics 20231020 2
Many autoimmune diseases are characterized by B cells that mistakenly recognize autoantigens and produce antibodies toward self-proteins. Current therapies aim to suppress the immune system, which is associated with adverse effects. An attractive and more specific approach is to target the autoreactive B cells selectively through their unique B-cell receptor (BCR) using an autoantigen coupled to an effector molecule able to modulate the B-cell activity. The cellular response upon antigen binding ...[more]