Africa-specific human genetic variation near CHD1L associates with HIV-1 load.

ABSTRACT: HIV-1 remains a global health crisis¹, highlighting the need to identify new targets for therapies. Here, given the disproportionate HIV-1 burden and marked human genome diversity in Africa², we assessed the genetic determinants of control of set-point viral load in 3,879 people of African ancestries living with HIV-1 participating in the international collaboration for the genomics of HIV³. We identify a previously undescribed association signal on chromosome 1 where the peak variant associates with an approximately 0.3 log₁₀-transformed copies per ml lower set-point viral load per minor allele copy and is specific to populations of African descent. The top associated variant is intergenic and lies between a long intergenic non-coding RNA (LINC0

SUBMITTER: McLaren PJ 

PROVIDER: S-EPMC10848312 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature