Dataset Information

Single cell analysis revealed that two distinct, unique CD4⁺ T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice.

ABSTRACT: Recent advances in research suggest that aging has a controllable chronic inflammatory disease aspect. Aging systemic T cells, which secrete pro-inflammatory factors, affect surrounding somatic cells, and accelerate the aging process through chronic inflammation, have attracted attention as potential therapeutic targets in aging. On the other hand, there are few reports on the aging of the intestinal immune system, which differs from the systemic immune system in many ways. In the current study, we investigated the age-related changes in the intestinal immune system, particularly in T cells. The most significant changes were observed in the CD4⁺ T cells in the small intestinal IEL, with a marked increase in this fraction in old mice and reduced expression of CD27 and CD28, which

SUBMITTER: Yonemoto Y

PROVIDER: S-EPMC10848332 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Single cell analysis revealed that two distinct, unique CD4⁺ T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Single cell analysis revealed that two distinct, unique CD4+ T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Single cell analysis revealed that two distinct, unique CD4⁺ T cell subsets were increased in the small intestinal intraepithelial lymphocytes of aged mice.