De-obstruction of bladder outlet in humans reverses organ remodelling by normalizing the expression of key transcription factors.

ABSTRACT:

Background

Benign prostatic hyperplasia in elderly males often causes bladder outlet obstruction termed benign prostatic obstruction (BPO). BPO induces lower urinary tract symptoms and quantifiable urodynamic alterations in bladder function. When conservative medical treatments are exhausted, surgical interventions like transurethral resection of the prostate (TURP) are employed for bladder outlet de-obstruction. Elucidating the molecular changes in the human bladder resulting from BPO and their reversal post-de-obstruction is pivotal for defining the "point of no return", when the organ deterioration becomes irreversible. In this study we carried out a comprehensive molecular and urodynamic characterization of the bladders in men with BPO before TURP and 3 months after the relief

SUBMITTER: Akshay A 

PROVIDER: S-EPMC10848355 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature