High-throughput nanoscale crystallization of dihydropyridine active pharmaceutical ingredients.

ABSTRACT: Single-crystal X-ray diffraction analysis of small molecule active pharmaceutical ingredients is a key technique in the confirmation of molecular connectivity, including absolute stereochemistry, as well as the solid-state form. However, accessing single crystals suitable for X-ray diffraction analysis of an active pharmaceutical ingredient can be experimentally laborious, especially considering the potential for multiple solid-state forms (solvates, hydrates and polymorphs). In recent years, methods for the exploration of experimental crystallization space of small molecules have undergone a `step-change', resulting in new high-throughput techniques becoming available. Here, the application of high-throughput encapsulated nanodroplet crystallization to a series of six dihydropyridines, ca

SUBMITTER: Metherall JP 

PROVIDER: S-EPMC10848412 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature