Enabling personalised disease diagnosis by combining a patient's time-specific gene expression profile with a biomedical knowledge base.

ABSTRACT:

Background

Recent developments in the domain of biomedical knowledge bases (KBs) open up new ways to exploit biomedical knowledge that is available in the form of KBs. Significant work has been done in the direction of biomedical KB creation and KB completion, specifically, those having gene-disease associations and other related entities. However, the use of such biomedical KBs in combination with patients' temporal clinical data still largely remains unexplored, but has the potential to immensely benefit medical diagnostic decision support systems.

Results

We propose two new algorithms, LOADDx and SCADDx, to combine a patient's gene expression data with gene-disease association and other related information available in the form of a KB, to assist personalized disease diag

SUBMITTER: Verma G 

PROVIDER: S-EPMC10848462 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature