Causal associations between gut microbiota, metabolites and asthma: a two-sample Mendelian randomization study.

ABSTRACT:

Background

While several traditional observational studies have suggested associations between gut microbiota and asthma, these studies are limited by factors such as participant selection bias, confounders, and reverse causality. Therefore, the causal relationship between gut microbiota and asthma remains uncertain.

Methods

We performed two-sample bi-directional Mendelian randomization (MR) analysis to investigate the potential causal relationships between gut microbiota and asthma as well as its phenotypes. We also conducted MR analysis to evaluate the causal effect of gut metabolites on asthma. Genetic variants for gut microbiota were obtained from the MiBioGen consortium, GWAS summary statistics for metabolites from the TwinsUK study and KORA study, and GWAS summary stat

SUBMITTER: Li J 

PROVIDER: S-EPMC10848467 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature