Ancestral alleles defined for 70 million cattle variants using a population-based likelihood ratio test.

ABSTRACT:

Background

The study of ancestral alleles provides insights into the evolutionary history, selection, and genetic structures of a population. In cattle, ancestral alleles are widely used in genetic analyses, including the detection of signatures of selection, determination of breed ancestry, and identification of admixture. Having a comprehensive list of ancestral alleles is expected to improve the accuracy of these genetic analyses. However, the list of ancestral alleles in cattle, especially at the whole genome sequence level, is far from complete. In fact, the current largest list of ancestral alleles (~ 42 million) represents less than 28% of the total number of detected variants in cattle. To address this issue and develop a genomic resource for evolutionary studies, we determ

SUBMITTER: Dorji J 

PROVIDER: S-EPMC10848479 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature