DNA damage response alterations in clear cell renal cell carcinoma: clinical, molecular, and prognostic implications.

ABSTRACT:

Background

DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic responses. Nonetheless, the characteristics and significance of DDR alterations in clear cell renal cell carcinoma (ccRCC) remain undefined. This study aimed to explore the predictive role, molecular mechanism, and tumor immune profile of DDR genes in ccRCC.

Methods

We prospectively sequenced 757 tumors and matched blood DNA samples from Chinese patients with ccRCC using next-generation sequencing (NGS) and analyzed data from 537 patients from The Cancer Genome Atlas (TCGA). A comprehensive analysis was performed.

Results

Fifty-two percent of Chinese patients with ccRCC harbored DDR gene mutations and 57% of TCGA patients. The immunotherapy treatment prognosis of patients wi

SUBMITTER: Jing X 

PROVIDER: S-EPMC10848511 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature