The nuclei of human adult stem cells can move within the cell and generate cellular protrusions to contact other cells.

ABSTRACT:

Background

The neuronal transdifferentiation of adult bone marrow cells (BMCs) is still considered an artifact based on an alternative explanation of experimental results supporting this phenomenon obtained over decades. However, recent studies have shown that following neural induction, BMCs enter an intermediate cellular state before adopting neural-like morphologies by active neurite extension and that binucleated BMCs can be formed independent of any cell fusion events. These findings provide evidence to reject the idea that BMC neural transdifferentiation is merely an experimental artifact. Therefore, understanding the intermediate states that cells pass through during transdifferentiation is crucial given their potential application in regenerative medicine and disease modell

SUBMITTER: Bueno C 

PROVIDER: S-EPMC10848534 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature