Oxygenation influences xylose fermentation and gene expression in the yeast genera Spathaspora and Scheffersomyces.

ABSTRACT:

Background

Cost-effective production of biofuels from lignocellulose requires the fermentation of D-xylose. Many yeast species within and closely related to the genera Spathaspora and Scheffersomyces (both of the order Serinales) natively assimilate and ferment xylose. Other species consume xylose inefficiently, leading to extracellular accumulation of xylitol. Xylitol excretion is thought to be due to the different cofactor requirements of the first two steps of xylose metabolism. Xylose reductase (XR) generally uses NADPH to reduce xylose to xylitol, while xylitol dehydrogenase (XDH) generally uses NAD⁺ to oxidize xylitol to xylulose, creating an imbalanced redox pathway. This imbalance is thought to be particularly consequential in hypoxic or anoxic environments.

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SUBMITTER: Barros KO 

PROVIDER: S-EPMC10848558 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature