The fate of the contact ion pair determines the photochemistry of coumarin-based photocleavable protecting groups.

ABSTRACT: Photocleavable protecting groups (PPGs) enable the precise spatiotemporal control over the release of a payload of interest, in particular a bioactive substance, through light irradiation. A crucial parameter that determines the practical applicability of PPGs is the efficiency of payload release, largely governed by the quantum yield of photolysis (QY). Understanding which parameters determine the QY will prove crucial for engineering improved PPGs and their effective future applications, especially in the emerging field of photopharmacology. The Contact Ion Pair (CIP) has been recognized as an important intermediate in the uncaging process, but the key influence of its fate on the quantum yield has not been explored yet, limiting our ability to design improved PPGs. Here, we demon

SUBMITTER: Schulte AM 

PROVIDER: S-EPMC10848663 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature