Modularized microrobot with lock-and-detachable modules for targeted cell delivery in bile duct.

ABSTRACT: The magnetic microrobots promise benefits in minimally invasive cell-based therapy. However, they generally suffer from an inevitable compromise between their magnetic responsiveness and biomedical functions. Herein, we report a modularized microrobot consisting of magnetic actuation (MA) and cell scaffold (CS) modules. The MA module with strong magnetism and pH-responsive deformability and the CS module with cell loading-release capabilities were fabricated by three-dimensional printing technique. Subsequently, assembly of modules was performed by designing a shaft-hole structure and customizing their relative dimensions, which enabled magnetic navigation in complex environments, while not deteriorating the cellular functionalities. On-demand disassembly at targeted lesion was then realiz

SUBMITTER: Su L 

PROVIDER: S-EPMC10848723 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature