Novel resistance ICEs carrying the <i>bla</i>_FIM-1 metallo-β-lactamase gene from an ST235 <i>Pseudomonas aeruginosa</i> sublineage.

ABSTRACT: FIM-1 is an acquired metallo-β-lactamase identified in a multidrug-resistant Pseudomonas aeruginosa (index strain FI-14/157) of clinical origin isolated in 2007 in Florence, Italy. Here we report on a second case of infection by FIM-1-positive P. aeruginosa (FI-17645), which occurred in 2020 in the same hospital. Both FIM-1-positive strains exhibited resistance to all anti-Pseudomonas antibiotics except colistin and cefiderocol. Comparative genomic characterization revealed that the two FIM-positive strains were closely related [core genome difference, 16 single nucleotide polymorphisms (SNPs)], suggesting a local circulation of similar strains. In the FI-14/157 index strain, the bla_FIM-1 gene was associated with an ISCR19-like element that lik

SUBMITTER: Antonelli A 

PROVIDER: S-EPMC10848763 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature