Nitric oxide-releasing prodrug for the treatment of complex <i>Mycobacterium abscessus</i> infections.

ABSTRACT: Non-tuberculosis mycobacteria (NTM) can cause severe respiratory infection in patients with underlying pulmonary conditions, and these infections are extremely difficult to treat. In this report, we evaluate a nitric oxide (NO)-releasing prodrug [methyl tris diazeniumdiolate (MD3)] against a panel of NTM clinical isolates and as a treatment for acute and chronic NTM infections in vivo. Its efficacy in inhibiting growth or killing mycobacteria was explored in vitro alongside evaluation of the impact to primary human airway epithelial tissue. Airway epithelial tissues remained viable after exposure at concentrations of MD3 needed to kill mycobacteria, with no inherent toxic effect from drug scaffold after NO liberation. Resistance studies conducted via serial passage with repre

SUBMITTER: McDonald RA 

PROVIDER: S-EPMC10848776 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature