Systemic multiomics evaluation of the therapeutic effect of Bacteroides species on liver cirrhosis in male mice.

ABSTRACT:

Importance

The human gut microbiome mediates bidirectional interaction within the gut-liver axis, while liver diseases, including liver cirrhosis, are very closely related to the state of the gut environment. Thus, improving the health of the gut-liver axis by targeting the intestinal microbiota is a potential therapeutic approach in hepatic diseases. This study examines changes in metabolomics and microbiome composition by treating bacteria derived from the human gut in mice with liver cirrhosis. Interorgan-based multiomics profiling coupled with functional examination demonstrated that the treatment of Bacteroides dorei pertained to protective effects on liver cirrhosis by normalizing the functional, metabolic, and metagenomic environment through the gut-liver axis. The st

SUBMITTER: Park YR 

PROVIDER: S-EPMC10848840 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature