Deficiency and altered phenotype of mucosal-associated invariant T cells in systemic sclerosis.

ABSTRACT:

Objective

Systemic sclerosis is an autoimmune disease characterized by fibrosis of the skin and internal organs including the lung. Mucosal-associated invariant T cells are innate-like T lymphocytes able to produce various cytokines and cytotoxic mediators such as granzyme B. A large body of evidence supports a role of mucosal-associated invariant T cells in autoimmune disease but more recent reports suggest also a potential role in fibrotic conditions. Therefore, we herein addressed the question as whether mucosal-associated invariant T cells may have an altered profile in systemic sclerosis.

Methods

Mucosal-associated invariant T cell frequency was analyzed by flow cytometry, using fresh peripheral blood from 74 consecutive systemic sclerosis patients who were compared to

SUBMITTER: Lesturgie-Talarek M 

PROVIDER: S-EPMC10848929 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature