Altered epidermal proliferation, differentiation, and lipid composition: Novel key elements in the vitiligo puzzle.

ABSTRACT: Vitiligo is an acquired skin depigmentation disease involving multiple pathogenetic mechanisms, which ultimately direct cytotoxic CD8⁺ cells to destroy melanocytes. Abnormalities have been described in several cells even in pigmented skin as an expression of a functional inherited defect. Keratinocytes regulate skin homeostasis by the assembly of a proper skin barrier and releasing and responding to cytokines and growth factors. Alterations in epidermal proliferation, differentiation, and lipid composition as triggers for immune response activation in vitiligo have not yet been investigated. By applying cellular and lipidomic approaches, we revealed a deregulated keratinocyte differentiation with altered lipid composition, associated with impaired energy metabolism and increased

SUBMITTER: Kovacs D 

PROVIDER: S-EPMC10848961 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature