AutoCore: A network-based definition of the core module of human autoimmunity and autoinflammation.

ABSTRACT: Although research on rare autoimmune and autoinflammatory diseases has enabled definition of nonredundant regulators of homeostasis in human immunity, because of the single gene-single disease nature of many of these diseases, contributing factors were mostly unveiled in sequential and noncoordinated individual studies. We used a network-based approach for integrating a set of 186 inborn errors of immunity with predominant autoimmunity/autoinflammation into a comprehensive map of human immune dysregulation, which we termed "AutoCore." The AutoCore is located centrally within the interactome of all protein-protein interactions, connecting and pinpointing multidisease markers for a range of common, polygenic autoimmune/autoinflammatory diseases. The AutoCore can be subdivided into 19 endotyp

SUBMITTER: Guthrie J 

PROVIDER: S-EPMC10848965 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature