Rapid fabrication of hydrophobic/hydrophilic patterns on paper substrates for paper spray mass spectrometry.

ABSTRACT: A simple, rapid chemical coating and patterning method was developed and optimized for paper-based substrates for use in paper spray mass spectrometry (PS-MS). A variety of chlorosilanes were explored for coating paper substrates, and their effectiveness in forming hydrophobic surfaces was characterized via contact angle goniometry, scanning electron microscopy, and energy dispersive X-ray spectroscopy. Trichloromethylsilane was selected as the primary coating agent because of the short time required to produce a hydrophobic surface (contact angle > 130°), as well as the ease of patterning. Patterning was performed using 3D-printed masks and an oxygen/plasma cleaner. Optimal mask thickness and oxygen/plasma cleaning parameters were determined to produce channels varying from 0.5 to

SUBMITTER: Arias A 

PROVIDER: S-EPMC10849044 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature