Transmission of Mobile Colistin Resistance (mcr-1) by Duodenoscope.

ABSTRACT:

Background

Clinicians increasingly utilize polymyxins for treatment of serious infections caused by multidrug-resistant gram-negative bacteria. Emergence of plasmid-mediated, mobile colistin resistance genes creates potential for rapid spread of polymyxin resistance. We investigated the possible transmission of Klebsiella pneumoniae carrying mcr-1 via duodenoscope and report the first documented healthcare transmission of mcr-1-harboring bacteria in the United States.

Methods

A field investigation, including screening targeted high-risk groups, evaluation of the duodenoscope, and genome sequencing of isolated organisms, was conducted. The study site included a tertiary care academic health center in Boston, Massachusetts, and extended to community locations in New England.

SUBMITTER: Shenoy ES 

PROVIDER: S-EPMC10849062 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature