Ontology highlight
ABSTRACT:
SUBMITTER: Hu Y
PROVIDER: S-EPMC10849194 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Hu Yaofeng Y Xiao Kai K Yang Hengyu H Liu Xiaoping X Zhang Chuanchao C Shi Qianqian Q
Briefings in bioinformatics 20240101 2
Recent advances in spatially resolved transcriptomics (SRT) have brought ever-increasing opportunities to characterize expression landscape in the context of tissue spatiality. Nevertheless, there still exist multiple challenges to accurately detect spatial functional regions in tissue. Here, we present a novel contrastive learning framework, SPAtially Contrastive variational AutoEncoder (SpaCAE), which contrasts transcriptomic signals of each spot and its spatial neighbors to achieve fine-grain ...[more]