The causal effects of age at menarche and age at menopause on sepsis: A two-sample Mendelian randomization analysis.

ABSTRACT:

Objectives

To determine whether the age at menarche (AAM) and the age at menopause (ANM) are causally related to the development of sepsis.

Methods

We performed a two-sample Mendelian randomization (MR) analysis by utilizing summary statistics from genome-wide association study (GWAS) datasets for both the exposure and outcome variables. Single nucleotide polymorphisms (SNPs) that exhibited significant associations with AAM and ANM were chosen as instrumental variables to estimate the causal effects on sepsis. Our study employed a variety of methods, including MR-Egger regression, weighted median estimation, inverse variance weighting, a simple model, and a weighted model. Odds ratios (ORs) along with their corresponding 95% confidence intervals (CIs) were used as the primar

SUBMITTER: Guo N 

PROVIDER: S-EPMC10849219 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature