Birth weight influences cardiac structure, function, and disease risk: evidence of a causal association.

ABSTRACT:

Background and aims

Low birth weight is a common pregnancy complication, which has been associated with higher risk of cardiometabolic disease in later life. Prior Mendelian randomization (MR) studies exploring this question do not distinguish the mechanistic contributions of variants that directly influence birth weight through the foetal genome (direct foetal effects), vs. variants influencing birth weight indirectly by causing an adverse intrauterine environment (indirect maternal effects). In this study, MR was used to assess whether birth weight, independent of intrauterine influences, is associated with cardiovascular disease risk and measures of adverse cardiac structure and function.

Methods

Uncorrelated (r2 < .001), genome-wide significant (P < 5 × 10-8) single nucl

SUBMITTER: Ardissino M 

PROVIDER: S-EPMC10849320 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature